{"id":636,"date":"2021-01-02T18:05:00","date_gmt":"2021-01-02T18:05:00","guid":{"rendered":"https:\/\/stop-depression-info.com\/blog\/?p=636"},"modified":"2021-01-22T18:05:26","modified_gmt":"2021-01-22T18:05:26","slug":"role-of-tryptophan-hydroxylase-in-the-etiology-of-depression","status":"publish","type":"post","link":"https:\/\/stop-depression-info.com\/blog\/role-of-tryptophan-hydroxylase-in-the-etiology-of-depression\/","title":{"rendered":"Role of tryptophan hydroxylase in the etiology of depression"},"content":{"rendered":"\n<p>Tryptophan hydroxylase&nbsp;has two&nbsp;isoforms&nbsp;, which are encoded by the TPH1&nbsp;and&nbsp;TPH2 genes.&nbsp;This enzyme is involved in the synthesis of melatonin and serotonin.&nbsp;Tryptophan hydroxylase&nbsp;accelerates the attachment of the OH group to 5-hydroxytryptophan.&nbsp;Isoform&nbsp;1 encoded by TPH1 is associated with the development of drug addiction and schizophrenia.&nbsp;Gene&nbsp;expression is noted in the nervous system and peripheral organs.&nbsp;Isoform&nbsp;2 of&nbsp;tryptophan hydroxylase&nbsp;affects the synthesis of serotonin (5-HT) in the brain.&nbsp;The TPH2 gene is located on chromosome 12q.&nbsp;It has been associated with the development of major depression.&nbsp;In 2005 P.&nbsp;Zill&nbsp;&nbsp;with co-authors discovered a functional polymorphism Arg441His, which led to a decrease in serotonin secretion by 80%.&nbsp;Several variants of the gene have been associated with suicidal behavior.&nbsp;The lack of serotonin synthesis was due to genetic variations in the TPH2 gene.&nbsp;They led to the development of unipolar depression.<\/p>\n\n\n\n<p>A meta-analysis of 183 articles devoted to genetic polymorphisms of 102 genes showed that variations in the genes&nbsp;<em>APOE&nbsp;<\/em>(&nbsp;apolipoprotein&nbsp;),&nbsp;<em>MTHFR&nbsp;<\/em>(methylene&nbsp;tetrahydrofolate&nbsp;reductase&nbsp;),&nbsp;<em>GNB3&nbsp;<\/em>(guanine nucleotide binding protein beta-3),&nbsp;<em>SLC6A4&nbsp;<\/em>(serotonin transporter) increase the risk of disease unipolar depression.&nbsp;<em><\/em><em>&nbsp;<\/em>&nbsp;<em><\/em>&nbsp;&nbsp;&nbsp;<em><\/em>&nbsp;&nbsp;<em><\/em>&nbsp;<\/p>\n\n\n\n<p>The presence of genetic markers of depression suggests a change in the concept of diagnosis and treatment of this disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tryptophan hydroxylase&nbsp;has two&nbsp;isoforms&nbsp;, which are encoded by the TPH1&nbsp;and&nbsp;TPH2 genes.&nbsp;This enzyme is involved in the synthesis of melatonin and serotonin.&nbsp;Tryptophan hydroxylase&nbsp;accelerates the attachment of the OH group to 5-hydroxytryptophan.&nbsp;Isoform&nbsp;1 encoded by TPH1 is associated with the development of drug addiction and schizophrenia.&nbsp;Gene&nbsp;expression is noted in the nervous system and peripheral<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/stop-depression-info.com\/blog\/wp-json\/wp\/v2\/posts\/636"}],"collection":[{"href":"https:\/\/stop-depression-info.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stop-depression-info.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stop-depression-info.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/stop-depression-info.com\/blog\/wp-json\/wp\/v2\/comments?post=636"}],"version-history":[{"count":1,"href":"https:\/\/stop-depression-info.com\/blog\/wp-json\/wp\/v2\/posts\/636\/revisions"}],"predecessor-version":[{"id":637,"href":"https:\/\/stop-depression-info.com\/blog\/wp-json\/wp\/v2\/posts\/636\/revisions\/637"}],"wp:attachment":[{"href":"https:\/\/stop-depression-info.com\/blog\/wp-json\/wp\/v2\/media?parent=636"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stop-depression-info.com\/blog\/wp-json\/wp\/v2\/categories?post=636"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stop-depression-info.com\/blog\/wp-json\/wp\/v2\/tags?post=636"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}